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he present study was to investigate the effect of biologically treated jojoba meal(TJM) by Asperigullis oryzae (Fk-923) on performance, digestibility coefficient, nutritive value, blood metabolic, and rumen characteristic of sheep. Twenty Barki male sheep were used in a randomized complete blocks designed trial (four groups of five sheep each) average body weight 36.42 +2.05 kg and aged 4-5 years old. Second experiment: Total of 40 female Barki sheep at 3-4 years old were used in an experiment were lasted for 150 days for early and late pregnancy. The experiment aimed to study the feed evaluation and productive of sheep feed on treated jojoba meal. Male and Female were fed diets: R1: Control treatment (yellow corn (40%), wheat bran (20%), cotton seed meal (30%), molasses (6%), salt (1.5%), limestone (2%), and (0.5%) mineral premix, R2: Yellow corn (40%), wheat bran (20%), cotton seed meal (20%), jojoba meal (10%), molasses (6%), salt (1.5%), limestone (2%) and (0.5%) mineral premix, R3: Yellow corn (40%), wheat bran (20%), cotton seed meal (10%), jojoba meal (20%), molasses (6%), salt (1.5%), limestone (2%) and (0.5%) mineral premix and R4: Yellow corn (40%), wheat bran (20%), jojoba meal (30%), molasses (6%), salt (1.5%), limestone (2%) and (0.5%) mineral premix. The results indicated that the high crude protein content in jojoba meal with fungus was associated with a lower crud fiber content. It is noted that the treated jojoba recorded an improvement in CP, CF. higher than the untreated jojoba meal. jojoba meal with fungus decreased the simmondsin contents from 5% in untreated jojoba meal to 0.17% JM treated. chemical analyses of CP and EE in the R4 were found to be higher than those of R3,R2 and R1,while crude fiber , NDF, ADF contents recorded lower values in R4 than other rations. Data of digestibility trail showed that treatments fed R1 and R3 recorded higher (P<0.05) of DM, CP, OM, EE, NDF and ADF digestibility compared to other diets. The TDN g/kg BW and TDN % were higher in R3 compared to the ether diets. The DCP as g/h//d and DCP of R1 , R3 and R4 were significantly (p<0.05) higher than R2. The higher NI, NF and total excretion were recorded by R4 compared to other diets. ruminal PH higher value was recorded in zero time and tended to decrease at 3hrs and 6hrs after feeding. Rumen ammonia–N concentration was increased at 3hrs and decrease at 6hrs after feeding. the supplemented ration showed higher (P<0.01) TVFA,s production 3hrs after feeding but lower (P<0.01) at 6hrs after feeding in R2 and R3 verses R1 and R4.Starting from 2hrs to 24hrs of incubation the R3and R4 combinations showed higher gas produced volume than R2 and control treatment. The highest potential of gas production soluble (a) and insoluble (b) for treated Jojoba meal with fungi. Total protein, albumin and Globulin were non significantly increase (P>0.05) in lambs fed R4 ration than in those fed R3 ,R1 and R2. the activity of ALT and AST enzyme was significantly. serum T3 and T4 levels showed numerical significant (P<0.05) increase for T4 in group fed R1 as compared with the other group. During the early pregnancy and late pregnancy, changes in body weight of sheep were not significant by type of diets. Birth weights of does were not varied significantly among groups. When compared with control ration R1 feeding lambs on R3 and R4 reduced the cost of one Kg DCP compared with lambs fed on R2 and control ration. This 20%, 30% level recorded the best economical efficiency under Egyptian conditions.